Questions and AnswersProf. Dr. Bhaghirat Singh

Dr. Bhagirath Singh, Scientific Director, Canadian Institute of Infection & Immunity

"There is urgent need to focus on emerging infections globally. This website brings people and issue together by engaging the research community, policy makers and funders of research and public. New opportunities and challenges in this area can be addressed by these collaborative interactions."

 

 

 

Selected publications: 
 
Marleau AM, Summers KL, Singh B (2008) Differential Contributions of APC Subsets to T Cell Activation in Nonobese Diabetic Mice. J Immunol. 180:5235-49. free full text
 
Nikoopour E, Schwartz JA, Singh B (2008) Therapeutic benefits of regulating inflammation in autoimmunity. Inflamm Allergy Drug Targets. 7: 203-210. abstract
 
Stephens TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S,  Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SM, Madrenas J, Singh B (2008) Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E. J. Immunol. 181: 6859-6871. abstract
 
Bocksch L, Rider BJ, Stephens T, Dai E, Liu L, Diao H, Viswanathan K, Munuswamy-Ramanujam G, Singh B, Lucas A (2007) C-terminal apolipoprotein E-derived peptide, Ep1.B, displays anti-atherogenic activity. Atherosclerosis 194: 116-124. doi:10.1016/j.atherosclerosis.2006.10.014
 
Qin HY, Mukherjee R, Lee-Chan E, Ewen C, Bleackley RC, Singh B (2006) A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunity. Int Immunol. 18:1001-15. doi:10.1093/intimm/dxl035
 
Summers KL, Marleau AM, Mahon JL, McManus R, Hramiak I, Singh B (2006) Reduced IFN-a secretion by blood dendritic cells in human diabetes. Clin Immunol 121:81-89. doi:10.1016/j.clim.2006.05.015
 
Mukherjee R, Wagar DA, Stephens TA, Lee-Chan E, Singh B (2005) Identification of CD4+ T cell specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) – a novel beta cell auto antigen in type 1 diabetes. J Immunol. 174: 5306-15. free full text
 
Qin HY, Chaturvedi P, Singh, B (2004) In vivo apoptosis of diabetogenic T cells in NOD mice by by IFN-gamma/TNF-alpha. Int Immunol. 16:1723-1732. doi:10.1093/intimm/dxh173

Singh B (2000) Stimulation of the developing immune system can prevent autoimmunity. J. Autoimmun. 14: 15-22. doi:10.1006/jaut.1999.0349

Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA (2000) B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12: 431-440. doi:10.1016/S1074-7613(00)80195-8

 

 

 

 

 

 

 

   

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Contact

Prof. Dr. Bhaghirat Singh
Scientific Director of the Institute of Infection and Immunity of the CIHR, Ottawa, Canada

Phone:+1 / 519-661-3228
Fax:+1 / 519-661-4226
Email:Klick me
http://www.cihr-irsc.gc.ca/iii...



Curriculum Vitae

Dr. Bhagirath Singh is currently Scientific Director of the Institute of Infection and Immunity of the Canadian Institutes of Health Research (CIHR), Professor in the Department of Microbiology and Immunology at the University of Western Ontario, and a Scientist at the Robarts Research Institute in London, Ontario.

After post-doctoral training at Liverpool University in England, he joined the Department of Immunology at the University of Alberta, Edmonton, Alberta in 1973 and became full Professor in 1986.

In 1992 he was recruited as Professor and Chair of the Department of Microbiology and Immunology at the University of Western Ontario, London, Ontario and co-director of the Immunology group at the Robarts Research Institute.

In 2001 he was appointed the founding Scientific Director of the CIHR Institute of Infection and Immunity.

Dr. Singh is recognized as a leader in the prevention and regulation of
autoimmune diseases by immunological approaches and impact of infections on the immune system in autoimmune diabetes.  His work on the regulation of autoimmune diabetes laid the foundation of the current “hygiene hypothesis” for autoimmune diseases.

He has published over 195 peer-reviewed papers. He was an Alberta Heritage Foundation for Medical Research Scholar and Scientist. He was responsible for providing a rapid research response to SARS threat in 2003 by creating Canadian SARS Research Consortium. He has coordinated the pandemic influenza threat through the formation of CIHR Pandemic Preparedness Strategic Research Initiative. In addition, he organized HIV/AIDS research for CIHR through the creation of CIHR HIV/AIDS Research Initiative and CIHR HIV/AIDS Research Advisory Committee.

Recently, he has been involved in the mobilizing the Canadian Microbiome Initiative to be part of global effort to help understand the diversity of microbes in human health and disease. He is currently focused on initiating new research effort on vaccine discovery at CIHR with various public and private sector partners. He has served on numerous national and international peer review committees and scientific advisory boards. He is recipient of many honours including the University of Western Ontario Faculty of Medicine Deans Award of Excellence, the Banting and Best Memorial Lectureship of the International Diabetes Federation, Bernhard Cinader Award Lectureship of the Canadian Society for Immunology.

He is elected Fellow of the Royal Society of Canada and the Canadian Academy of Health Sciences.