Perspectives

Perspectives contains in depth articles on key topics in infection research.

21 June 2010 | Anna Holzscheiter

Infectious disease governance – a globalised yet divided world

 
The Millenium Development Goals, among other things, aim at relieving developing countries from the heavy burden of infectious diseases. But the resoping countries from the heavy burden of infectious...
The Millenium Development Goals, among other things, aim at relieving developing countries from the heavy burden of infectious diseases. But the results achieved so far are sobering.

The swine flu pandemic once again highlighted the wide gap that exists between developing and developed countries in terms of their ability to provide the drugs, health services, logistics and wider medical infrastructure necessary for the rapid protection of citizens from communicable diseases. While industrialised countries were able to develop and acquire large quantities of vaccinations, particularly for most at risk populations, the health systems and health budgets of many developing countries would not be able to shoulder the burden of disease of such a pandemic, facing large numbers of deaths.

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22 March 2010   Dr. Kristen Kerksiek

Farming out Antibiotics: The fast track to the post-antibiotic era

 
Pigs are often colonized but rarely infected with the livestock-borne MRSA strain CC398. © Simone van den Berg / Fotolia.com
Pigs are often colonized but rarely infected with the livestock-borne MRSA strain CC398. © Simone van den Berg / Fotolia.com

There was a time when a simple cut could be a death sentence and when untreatable bacterial diseases such as tuberculosis and syphilis claimed men and women in the prime of their lives. Antibiotics changed the world. It’s hard for us now to imagine a world without these “wonder drugs”, but with the dramatic increase in antibiotic resistance, it has unfortunately become less of a stretch of the imagination. And for some unlucky individuals who get the wrong resistant infection at the wrong time, the post-antibiotic era has become reality.

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17 January 2010 Dr. Kristen Kerksiek

Getting down to the core of the problem: Microbiota and diseases of the modern world

 
Do our gut microbes share some blame for the rise in obesity? © bacalao/fotolia.com
Do our gut microbes share some blame for the rise in obesity? © bacalao/fotolia.com

Its depths are teeming with life, an ancient and complex ecosystem that we don’t fully know or understand. Over thousands of years, this community has evolved to ward off pathogenic microorganisms, participate in digestion, synthesize essential nutrients and train the immune system. However, it seems that a fragile balance has been damaged, and it’s probably affecting our health.

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27 November 2009 Dr. Kristen Kerksiek

An indefinable risk: when microbes become weapons

 
Biohazard: Are we ready for the worst-case scenario? © Austrian Armed Forces
Biohazard: Are we ready for the worst-case scenario? © Austrian Armed Forces

You feel miserable. Fever, headache, backache, nausea, exhaustion…maybe it’s that virus that’s been going around the office. Then your fever goes down, but a red rash appears on your face and then your arms and legs. You’re not prepared for what happens next: hospital, quarantine, tests… others with the same symptoms! And then you hear a word that you’d almost forgotten: bioterrorism.

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29 October 2009 Dr. Kristen Kerksiek

The Art of Infection

 
In his Isenheim Altarpiece, Matthias Grünewald incorporated figures with skin disease (most likely St. Anthony’s Fire (ergotism)).
In his Isenheim Altarpiece, Matthias Grünewald incorporated figures with skin disease (most likely St. Anthony’s Fire (ergotism)). ####

Pablo Picasso once wrote, "Painting is just another way of keeping a diary". Artists often find their inspiration in everyday life, and since infectious diseases have been faithful and dedicated companions of the human race, it’s probably safe to assume that most artists encountered – and were influenced by - infection. But given the deep and mysterious ways of artists, it’s often difficult to "find" that influence in their works; it’s a job best left to the endless debates of art historians. There are diseases, however, that have taken hold of society, clearly affecting all facets of human life. Including expression through art.

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22 September 2009 Dr. Kristen Kerksiek

Tuberculosis: A long story with an open ending

 
Far from conquered, TB is threatening a new epidemic. © National Library of Medicine (NLM)
Far from conquered, TB is threatening a new epidemic. © National Library of Medicine (NLM)

Most epidemics come and go again. It might take weeks, months or even years, but the time can be marked – no comfort to the afflicted, of course – in a fraction of a lifetime. For epidemics of tuberculosis (TB), however, another scale must be adopted: centuries can go by before the disease loses its hold on the population. The Great White Plague, the TB epidemic that hit Europe in the 17th century, lasted for more than two centuries and was responsible for up to 25% of deaths at times.

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25 August 2009 Dr. Kristen Kerksiek

Shape Matters: Why bacteria care how they look

 
Antony van Leeuwenhoek (1632-1723) built simple microscopes that enabled him to magnify ob-jects – clearly and brightly - greater than 250x.
Antony van Leeuwenhoek

Rods, cocci, spirals... Bacteria are found in a wide array of different shapes. It doesn't occur by chance, but scientists are only starting to understand how selective pressures in the environment "shape" bacterial morphology.

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09 July 2009 Dr. Kristen Kerksiek

Rickettsia: old enemies newly defined

 
Howard Taylor Ricketts was a dedicated researcher known to inject himself with pathogens to test their effects.
Howard Taylor Ricketts was a dedicated researcher known to inject himself with pathogens to test their effects.

Russia, 1918. World War I was over but a tiny enemy was still on the move. It had killed millions – on both sides - during the war but wasn’t finished. By 1922 it had struck at least three million famine-struck civilians. The deadly adversary was Rickettsia prowazekii, a tiny bacterium that causes epidemic typhus.

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10 June 2009 Dr. Kristen Kerksiek

A tick too close: the emerging threat of tick-borne diseases

 
A tick of the genus Ixodes ricinus © www.zecken.de
A tick of the genus Ixodes ricinus © www.zecken.de

It’s that time again - the season for hiking, bathing, grilling… and a badly needed blood meal. The mosquitoes are thrilled! We – as the blood meal – don’t share their excitement, but for those of us living in temperate regions, mosquitoes are – with a few exceptions - a nuisance but not much of a health threat. But don’t put down your defenses! Another bloodsucker is on the prowl. In mild, moist climates, ticks are in their element and are vectors of some nasty diseases.

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19 May 2009 Dr. Kristen Kerksiek

Dying for Clean Water

 
Irdimi refugee camp, Tschad: A fugitive girl collects water from a well. © UNO-Flüchtlingshilfe
Irdimi refugee camp, Tschad: A fugitive girl collects water from a well. © UNO-Flüchtlingshilfe

An estimated 1.1 billion people don’t have access to safe drinking water, and more than twice as many live with inadequate sanitation. While the consequence is predictable, the numbers are staggering: lack of clean drinking water causes more than 2 million deaths each year, 90% of which are children under the age of five. The microbial culprits are well-known, and the infections they cause are for the most part both preventable and treatable.

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